反应详情

温度

160 °C

To 2 ml of triethyl phosphite was added 0.374 g of 8-chloromethyl-10H-pyrazino[2,3-b][1,4]benzothiazine and the resulting mixture was heated to 160° C. for 3 hours. Then the reaction mixture was brought back to room temperature and diethyl ether (10 ml) and n-hexane (20 ml) were added thereto. The precipitate was taken up by filtration and washed several times with n-hexane to thereby give 0.413 g of the title compound as a yellow powder.

1. customwas brought back to room temperature
2. filtrationThe precipitate was taken up by filtration
3. washwashed several times with n-hexane