HCID 18670225, compound → HCID 18670732, compound

HRID 1059416Notes

Reaction equation

HRID 1059416 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[CH:9][C:10]1[CH:11]=[CH:12][C:13]2[S:18][C:17]3[N:19]=[CH:20][CH:21]=[N:22][C:16]=3[N:15]([CH2:23][O:24][CH3:25])[C:14]=2[CH:26]=1>N1C=CC=CC=1>[N:8]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[NH:1][C:9]=1[C:10]1[CH:11]=[CH:12][C:13]2[S:18][C:17]3[N:19]=[CH:20][CH:21]=[N:22][C:16]=3[N:15]([CH2:23][O:24][CH3:25])[C:14]=2[CH:26]=1

Participants

3

Reactant 1

HCID 18670225HCID 18670225, compound

Product 1

HCID 18670732HCID 18670732, compoundYield 51.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

610 mg of 2-amino-1-[N-[(10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)methylene]]aminobenzene was heated under reflux in 3 ml of pyridine for 8 hours. Then the reaction mixture was brought back to room temperature and eluted with ethyl acetate. The crystals thus precipitated were ground and filtered to thereby give 310 mg of the title compound as yellow crystals.

Workup

  1. customwas brought back to room temperature
  2. washeluted with ethyl acetate
  3. customThe crystals thus precipitated
  4. filtrationfiltered

Sources & evidence

ORD record
ord-29b2ef93312d453fa4be54876b2f961f
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

Loading…