Diethyl Ether → N-(10-Methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)acetamide

HRID 1059429Notes

Reaction equation

HRID 1059429 reaction equation
C(O[C:5](=[O:7])[CH3:6])(=O)C.[NH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]2[S:18][C:17]3[N:19]=[CH:20][CH:21]=[N:22][C:16]=3[N:15]([CH2:23][O:24][CH3:25])[C:14]=2[CH:26]=1.C(OCC)C>ClCCl>[CH3:25][O:24][CH2:23][N:15]1[C:14]2[CH:26]=[C:10]([CH2:9][NH:8][C:5](=[O:7])[CH3:6])[CH:11]=[CH:12][C:13]=2[S:18][C:17]2[N:19]=[CH:20][CH:21]=[N:22][C:16]1=2

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 7918Acetic AnhydrideHCID 186704238-aminomethyl-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine

Product 1

HCID 18670470N-(10-Methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)acetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1 ml of acetic anhydride was added to 5 ml of a solution of 350 mg of 8-aminomethyl-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine in dichloromethane and the resulting mixture was stirred at room temperature for 2 hours. After adding diethyl ether, the precipitate thus formed was taken up by filtration to thereby give 350 mg of the title compound as yellow crystals.

Workup

  1. customthe precipitate thus formed
  2. filtrationwas taken up by filtration

Sources & evidence

ORD record
ord-5209dec517d84d2eb21c6e845ba7a3e2
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

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