Methanol → HCID 18670150, compound

Participants

Reaction Conditions

Reaction Steps

250 mg of N-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)-N′-benzoylthiourea was added to a mixture of a 20% aqueous solution of potassium hydroxide (5 ml) with methanol (5 ml). After further adding a small portion of tetrahydrofuran, the resulting mixture was heated to 50° C. for 5 minutes. Then the reaction mixture was brought back to room temperature and distributed into water and ethyl acetate. The organic layer was extracted, washed with water and dried over anhydrous sodium sulfate. After distilling off the solvent under reduced pressure, the crystals thus precipitated were suspended in ethyl acetate and filtered. Thus, 140 mg of the title compound was obtained as yellow crystals.

Provenance & Evidence