Purine → HCID 18670198, compound

Participants

Reaction Steps

In accordance with the procedure of Example 1094, 740 mg of 8-chloromethyl-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine was reacted with 460 mg of purine in the presence of sodium hydride (60% oily) in N,N-dimethylformamide (10 ml). The two isomers thus obtained were purified by silica gel column chromatography (eluted with dichloromethane/methanol) to thereby give 320 mg of 8-(purin-9-ylmethyl)-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine and 125 mg of 8-(purin-7-ylmethyl)-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine each as yellow crystals.

Provenance & Evidence