2-Methyl-3-butyn-2-ol → HCID 18670368, compound

HRID 1059442Notes

Reaction equation

HRID 1059442 reaction equation
I[C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH2:11][C:12]1[CH:13]=[CH:14][C:15]2[S:20][C:19]3[N:21]=[CH:22][CH:23]=[N:24][C:18]=3[N:17](COC)[C:16]=2[CH:28]=1.IC1N=CN=C2C=1N=CN2CC1C=CC2SC3N=CC=NC=3NC=2C=1.[CH3:54][C:55]([OH:59])([C:57]#[CH:58])[CH3:56]>>[N:24]1[C:18]2[NH:17][C:16]3[CH:28]=[C:12]([CH2:11][N:6]4[CH:5]=[N:4][C:3]5[C:7]4=[N:8][CH:9]=[N:10][C:2]=5[C:58]#[C:57][C:55]([CH3:56])([OH:59])[CH3:54])[CH:13]=[CH:14][C:15]=3[S:20][C:19]=2[N:21]=[CH:22][CH:23]=1

Participants

4

Reactant 3

HCID 82582-Methyl-3-butyn-2-olHCID 18670284HCID 18670284, compoundHCID 18670338HCID 18670338, compound

Product 1

HCID 18670368HCID 18670368, compound

Procedure

8-(6-Iodopurin-9-ylmethyl)-10-methoxymethyl-10H-pyrazino[2,3-b][1,4]benzothiazine was treated by the same method as the one of Example 9 to thereby give 8-(6-iodopurin-9-ylmethyl)-10H-pyrazino[2,3-b][1,4]benzothiazine. Next, this product was treated with 2-methyl-3-butyn-2-ol by the same method as the one of Example 1417 to thereby give the title compound.

Sources & evidence

ORD record
ord-8e128f4173f14fd5a53e7a6517596f28
Source dataset
uspto-grants-2003_02
Patent number
US06518423B1

Reaction notes

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