Cyanamide → HCID 18670275, compound

Participants

Reaction Steps

To 15 ml of a solution of 410 mg of methyl (10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)acetothioimidate in methanol was added 250 mg of cyanamide and the resulting mixture was heated to 60° C. or below for 1 hour. Then the reaction mixture was brought back to room temperature and the solvent was distilled off under reduced pressure to reduce its amount. The crystals thus precipitated were taken up by filtration and washed successively with methanol and ethyl acetate. Thus, 295 mg of the title compound was obtained as yellow crystals.

Provenance & Evidence