Dimethylformamide → HCID 178504028, compound

Participants

Reaction Steps

To a solution of 1.0 g of N-(10H-pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)thiourea in acetone (10 ml)/N,N-dimethylformamide (10 ml) was added 1.0 ml of methyl iodide and the resulting mixture was stirred at room temperature for 0.5 hour. Next, the reaction mixture was distributed into an aqueous solution of potassium carbonate and ethyl acetate. The organic layer was extracted and washed with water. After distilling off the solvent under reduced pressure, the crystals thus precipitated were taken up by filtration and washed with ethyl acetate to thereby give 0.900 g of the title compound as yellow crystals.

Provenance & Evidence