Water → HCID 23564892, compound

Participants

Reaction Steps

To a solution of 4.0 g of 8-(tert-butyldimethylsiloxymethyl)-10H-pyrazino[2,3-b][1,4]benzothiazine in 50 ml of N,N-dimethylformamide was added 0.73 g of sodium hydride (60%) and the resulting mixture was stirred for 10 minutes. After adding 1.4 ml of acetyl chloride thereto, the resulting mixture was reacted at room temperature for 10 minutes. After adding water followed by extraction with ethyl acetate, the extract was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. After distilling off the solvent under reduced pressure, the residue was purified by silica gel column chromatography (eluting with ethyl acetate/hexane) to thereby give 2.5 g of the title compound as a yellow oily substance.

Provenance & Evidence