HCID 18629908, compound → HCID 18629912, compound

Participants

Reaction Steps

The mixture of 5-nitro-2-benzoxazoleacetonitrile (8 g 39.4 mmole) and Palladium on carbon (1.2 g) in THF (100 ml) and acetic acid (2 ml) in a Parr bottle was hydrogenated at 50 psi for 5 h. It was filtered over a patch of celite (1.5 cm) covered with activated carbon (0.5 cm) and washed with isopropyl ether. The filtrate was evaporated and the residue was purified by flash chromatography and gave 5-amino-2-benzoxazoleacetonitrile (2.02 g, 30%).

Provenance & Evidence