Sodium Hydroxide → HCID 12056725, compound

HRID 1059686Notes

Reaction equation

HRID 1059686 reaction equation
C([O:4][CH:5]([C:7]1[N:12]=[CH:11][N:10]=[C:9]([Cl:13])[C:8]=1[I:14])[CH3:6])(=O)C.[OH-].[Na+]>C(O)C>[Cl:13][C:9]1[C:8]([I:14])=[C:7]([CH:5]([OH:4])[CH3:6])[N:12]=[CH:11][N:10]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12056724HCID 12056724, compound

Product 1

HCID 12056725HCID 12056725, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol (20 ml) was dissolved 6-(1-acetoxyethyl)-4-chloro-5-iodopyrimidine (1.0 g), and 1N sodium hydroxide aqueous solution (20 ml) was added dropwise to the solution while stirring. After the dropping addition, the mixture was stirred for additional one hour at room temperature to complete the reaction. Then, the solvent was distilled off under reduced pressure, and the desired compound was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure.

Workup

  1. additionwas added dropwise to the solution
  2. additionAfter the dropping addition
  3. stirringthe mixture was stirred for additional one hour at room temperature
  4. customthe reaction
  5. distillationThen, the solvent was distilled off under reduced pressure
  6. extractionthe desired compound was extracted with ethyl acetate
  7. washThe extract was washed with water
  8. dry with materialdried over anhydrous sodium sulfate
  9. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-6e6306d617d24b7b985ae2fe3c552a8b
Source dataset
uspto-grants-2003_02
Patent number
US06521627B1

Reaction notes

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