反应详情

In ethanol (20 ml) was dissolved 6-(1-acetoxyethyl)-4-chloro-5-iodopyrimidine (1.0 g), and 1N sodium hydroxide aqueous solution (20 ml) was added dropwise to the solution while stirring. After the dropping addition, the mixture was stirred for additional one hour at room temperature to complete the reaction. Then, the solvent was distilled off under reduced pressure, and the desired compound was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure.

1. additionwas added dropwise to the solution
2. additionAfter the dropping addition
3. stirringthe mixture was stirred for additional one hour at room temperature
4. customthe reaction
5. distillationThen, the solvent was distilled off under reduced pressure
6. extractionthe desired compound was extracted with ethyl acetate
7. washThe extract was washed with water
8. dry with materialdried over anhydrous sodium sulfate
9. distillationthe solvent was distilled off under reduced pressure