HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1059691Generated: October 26, 2026
Triethylamine → 6-(1-Bromoethyl)-5-iodo-4-[2-(4-trifluoromethoxyphenyl)ethylamino]pyrimidine
https://huagongshe.com/reaction/1059691
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-[4-(Trifluoromethoxy)phenyl]ethan-1-amine | HCID 10632040 | — |
| Reactant | HCID 18630910 | HCID 18630910 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 6-(1-Bromoethyl)-5-iodo-4-[2-(4-trifluoromethoxyphenyl)ethylamino]pyrimidine | HCID 15452307 | — |
Reaction Steps
In toluene (50 ml) were dissolved 2-(4-trifluoromethoxyphenyl)ethylamine (1.0 g) and triethylamine (1.0 g) then, 4-chloro-6-(1-bromoethyl)-5-iodopyrimidine (1.8 g) was added to the solution, and the mixture was heated at about 60° C. for 3 hours while stirring.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06521627B1 |
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| Source dataset | uspto-grants-2003_02 |
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| ORD ID | ord-4b95f2dce02e416db7c76b7510e5f33d |
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| Source note | uspto-grants-2003_02 |
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