HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 1,2-Dimethyl-1H-indol-5-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1,2-Dimethyl-5-nitro-1h-indole | HCID 280485 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1,2-Dimethyl-1H-indol-5-amine | HCID 6484710 | — |
Reaction Steps
A solution of 1,2-dimethyl-5-nitro-1H-indole (500 mg) in 1:1 THF:methanol (10 mL) was treated with 10% palladium on carbon (100 mg), stirred under hydrogen (1 atm) for 1 hour, filtered through diatomaceous earth (Celite®), and concentrated. The crude product was used without further purification in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06521658B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-8c329090a5f449ebaa23bd01e40af0d8 |
| Source note | uspto-grants-2003_02 |