4-Methoxybenzenethiol → 1,2,3-Trimethoxy-5-(((4-methoxyphenyl)sulfanyl)methyl)benzene

HRID 1059852Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([SH:9])=[CH:5][CH:4]=1.Cl[CH2:11][C:12]1[CH:13]=[C:14]([O:22][CH3:23])[C:15]([O:20][CH3:21])=[C:16]([O:18][CH3:19])[CH:17]=1.ClCC1C=CC(OC)=CC=1>>[CH3:19][O:18][C:16]1[CH:17]=[C:12]([CH2:11][S:9][C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH:13]=[C:14]([O:22][CH3:23])[C:15]=1[O:20][CH3:21]

Participants

Reactant 3

HCID 127654-Methoxybenzenethiol

HCID 699934-Methyloxybenzyl chloride

HCID 774485-(Chloromethyl)-1,2,3-trimethoxybenzene

Product 1

HCID 101257191,2,3-Trimethoxy-5-(((4-methoxyphenyl)sulfanyl)methyl)benzene

Procedure

The desired product was prepared by substituting 4-methoxybenzenethiol and 5-(chloromethyl)-1,2,3-trimethoxybenzene for Example 85A and l-(chloromethyl)-4-methoxybenzene, respectively, in Example 85B.

Sources & evidence

ORD record: ord-07ac436ce17d4362bcf700bc5bc4a53b
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06521658B1

Reaction notes

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