Ethylamine → HCID 178464612, compound

HRID 1059879Notes

Reaction equation

HRID 1059879 reaction equation
[CH2:1]([NH2:3])[CH3:2].[CH3:4][C:5]1[N:6]=[C:7]([NH:17][C:18](=[NH:22])SCC)[S:8][C:9]=1[C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[CH:12][N:11]=1>C(O)C>[CH2:1]([NH:3][C:18]([NH:17][C:7]1[S:8][C:9]([C:10]2[CH:15]=[C:14]([CH3:16])[CH:13]=[CH:12][N:11]=2)=[C:5]([CH3:4])[N:6]=1)=[NH:22])[CH3:2]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 178477486HCID 178477486, compound

Product 1

HCID 178464612HCID 178464612, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethylamine in ethanol (20% w/w, 10 ml) was added N-(4-methyl-5-(4-methylpyridin-2-yl)thiazol-2-yl)-S-ethylisothiourea (292 mg), and the mixture was heated in a steel autoclave at 110° C. for 17 hours. The mixture was evaporated under reduced pressure and crystallized from ethanol. The precipitate was collected by filtration to give N-ethyl-N′-(4-methyl-5-(4-methylpyridin-2-yl)-thiazol-2-yl)guanidine (124 mg).

Workup

  1. customThe mixture was evaporated under reduced pressure
  2. customcrystallized from ethanol
  3. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-b6bdae4cbd124fc8b42efb6b119b637a
Source dataset
uspto-grants-2003_02
Patent number
US06521643B1

Reaction notes

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