Triethylsilane → HCID 178428496, compound

Participants

Reaction Steps

A solution of N-(5-(hydroxy-(4-methylpyridin-2-yl)methyl)-4-methylthiazol-2-yl)guanidine (65 mg) and triethylsilane (300 mg) in trifluoroacetic acid (3 ml) was stirred for 48 hours and then evaporated under reduced pressure. Water was added, and the pH was adjusted to 12 with 4N aqueous sodium hydroxide. The resultant mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate and-evaporated under reduced pressure. The residue was crystallized from dichloromethane to give N-(5-(4-methylpyridin-2-ylmethyl)-4-methylthiazol-2-yl)-guanidine (27 mg).

Provenance & Evidence