HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1059902Generated: October 27, 2026
Water → 1-(4-Methylpyridin-2-yl)-4-nitroimidazole
https://huagongshe.com/reaction/1059902
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Fluoro-4-methylpyridine | HCID 2737403 | — |
| Reactant | HCID 178526856 | HCID 178526856 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(4-Methylpyridin-2-yl)-4-nitroimidazole | HCID 18667530 | 34.2% |
Reaction Steps
A suspension of 2-fluoro-4-methylpyridine (1.11 g), 4-nitroimidazole (1.24 g) and potassium carbonate (1.65 g) in N,N-dimethylformamide (10 ml) was stirred at 130° C. for 21 hours. After cooling, the mixture was poured into water and stirred for 30 minutes. The precipitate was collected by filtration and dried to give 1-(4-methylpyridin-2-yl)-4-nitroimidazole (698 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06521643B1 |
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| Source dataset | uspto-grants-2003_02 |
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| ORD ID | ord-2ceb02fc828b4cbaac92eb82a39c502a |
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| Source note | uspto-grants-2003_02 |
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