Hydrochloric Acid → 3-(3-Trifluoromethylpyridin-2-yl) phenylguanidine dihydrochloride

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Reaction Steps

To a solution of N,N′-bis(tert-butoxycarbonyl)-N″-(3-(3-trifluoromethylpyridin-2-yl)phenyl)guanidine (200 mg) in dichloromethane (2 ml) was added 4N hydrogen chloride in 1,4-dioxane (4 ml), and the mixture was stirred at room temperature for 18 hours. The solvent was evaporated under reduced pressure. To the residue was added 5% ethanol in ethyl acetate (100 ml), and the precipitate was collected by filtration and dried under reduced pressure to give 3-(3-trifluoromethylpyridin-2-yl) phenylguanidine dihydrochloride (111 mg).

Provenance & Evidence