反应详情

A suspension of N,N′-bis(tert-butoxycarbonyl)-N″-(3-(3-nitropyridin-2-yl)phenyl)guanidine (520 mg) in ethanol (15 ml) was hydrogenated over palladium on carbon (10% w/w, 50% wet, 500 mg) under a hydrogen atmosphere for 24 hours. The catalyst was filtered off, and the filtrate was evaporated under reduced pressure. The residue was triturated with ethanol, filtered, and dried to give N,N′-bis(tert-butoxycarbonyl)-N″-(3-(3-aminopyridin-2-yl)phenyl)guanidine (325 mg).

1. filtrationThe catalyst was filtered off
2. customthe filtrate was evaporated under reduced pressure
3. customThe residue was triturated with ethanol
4. filtrationfiltered
5. customdried