HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Methoxypyridin-2-yl)-2-nitrotoluene → 5-(4-Methoxypyridin-2-yl)-2-methylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Methoxypyridin-2-yl)-2-nitrotoluene | HCID 18631003 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-(4-Methoxypyridin-2-yl)-2-methylaniline | HCID 18667638 | 96.5% |
Reaction Steps
A suspension of 4-(4-methoxypyridin-2-yl)-2-nitrotoluene (300 mg) in tetrahydrofuran (3 ml) and ethanol (3 ml) was hydrogenated over palladium on carbon (10% w/w, 50% wet, 150 mg) under a hydrogen atmosphere for 3 hours. The catalyst was filtered off, and the filtrate was evaporated under reduced pressure to give 5-(4-methoxypyridin-2-yl)-2-methylaniline (254 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06521643B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-6ba881de2be0410e8f67d1743402cb68 |
| Source note | uspto-grants-2003_02 |