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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1059983Generated: October 30, 2026

HCID 18667517, compound → HCID 18667622, compound

https://huagongshe.com/reaction/1059983

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 18667517HCID 18667517—
CatalystPalladiumHCID 23938—
SolventEthanolHCID 702—
SolventTetrahydrofuranHCID 8028—
ProductHCID 18667622HCID 18667622100.1%

Reaction Steps

A suspension of 2-fluoro-5-(4-methoxypyridin-2-yl)nitrobenzene (0.2 g) in ethanol (4 ml) and tetrahydrofuran (3 ml) was hydrogenated over palladium on carbon (10% w/w, 50% wet, 60 mg) under a hydrogen atmosphere for 5 hours. The catalyst was filtered off, and the filtrate was evaporated under reduced pressure to give 2-fluoro-5-(4-methoxypyridin-2-yl)aniline (176 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06521643B1
Source datasetuspto-grants-2003_02
ORD IDord-bdf20f9a096d4f1c9ee0aa684a5e9ce7
Source noteuspto-grants-2003_02