反应详情

温度

50 °C

To a stirred solution of ammonium isothiocyanate (142 mg) in acetone (3 ml) was added benzoyl chloride (0.199 ml) at 50° C., and the mixture was stirred at 50° C. for 10 minutes. To the resultant suspension was added a solution of 3-(4-methylpyridin-2-yl)aniline (300 mg) in acetone (6 ml) dropwise, and the mixture was stirred at 60° C. for 2 hours. Water was added to the reaction mixture, and the precipitate was collected by filtration and dried to give N-(3-(4-methylpyridin-2-yl)phenyl)-N′-benzoylthiourea (557 mg).

1. stirringthe mixture was stirred at 60° C. for 2 hours
2. filtrationthe precipitate was collected by filtration
3. customdried