Hydrochloric Acid → HCID 18631026, compound

Participants

Reaction Steps

To a suspension of N-(2-fluoro-5-(4-methoxypyridin-2-yl)phenyl)-N′-benzoylthiourea (0.32 g) in methanol (3 ml) was added an aqueous sodium hydroxide solution (1N, 1 ml) dropwise. The mixture was stirred at ambient temperature for 4 hours, and the pH was adjusted to 8.0 with 1N hydrochloric acid. The precipitate was triturated with water, collected by filtration, washed with water and dried under reduced pressure to give N-(2-fluoro-5-(4-methoxypyridin-2-yl)-phenyl)thiourea (216 mg).

Provenance & Evidence