反应详情

To a suspension of N-(3-(4-methoxypyridin-2-yl)phenyl)thiourea (122 mg) in N,N-dimethylformamide (2.5 ml) were added a solution of hydrogen chloride in 1,4-dioxane (4N, 0.25 ml) and iodomethane (0.156 ml), and the mixture was stirred at ambient temperature for 5 hours. Ethyl acetate (100 ml) was added to the mixture, and the mixture was cooled. The precipitate was collected by filtration. The precipitate was dissolved in water, and to the solution was added a saturated aqueous sodium hydrogencarbonate solution and extracted with dichloromethane. The organic layer was washed with brine, dried over sodium sulfate and evaporated under reduced pressure. The residue was dissolved in ethyl acetate, and to the solution was added a solution of hydrogen chloride in 1,4-dioxane (4N, 0.5 ml). The precipitate was collected by filtration and dried under reduced pressure to give N-(3-(4-methoxypyridin-2-yl)phenyl)-S-methylisothiourea dihydrochloride (153 mg).

1. temperaturethe mixture was cooled
2. filtrationThe precipitate was collected by filtration
3. dissolutionThe precipitate was dissolved in water
4. additionto the solution was added a saturated aqueous sodium hydrogencarbonate solution
5. extractionextracted with dichloromethane
6. washThe organic layer was washed with brine
7. dry with materialdried over sodium sulfate
8. customevaporated under reduced pressure
9. dissolutionThe residue was dissolved in ethyl acetate
10. additionto the solution was added a solution of hydrogen chloride in 1,4-dioxane (4N, 0.5 ml)
11. filtrationThe precipitate was collected by filtration
12. customdried under reduced pressure