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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1060090Generated: October 27, 2026

N,N-diethyl-m-toluamide → N,N-Diethyl-5-methyl-2-(trimethylsilyl)benzamide

https://huagongshe.com/reaction/1060090

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,N-diethyl-m-toluamideHCID 4284—
ReactantChlorotrimethylsilaneHCID 6397—
ProductN,N-Diethyl-5-methyl-2-(trimethylsilyl)benzamideHCID 1863027546%

Reaction Steps

These compounds were prepared from N,N-diethyl-3-methylbenzamide and 2.0 eq TMSCl according to General Method A. Purification by HPLC using 1:9 ethyl acetate/hexanes gave two products. Compound 63 was isolated as 6.0 g of a clear oil, a 46% yield. Compound 64 was isolated as 2.3 g of a clear oil, a 17% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06521603B2
Source datasetuspto-grants-2003_02
ORD IDord-f10554688d544da88153b06c5ea7df55
Source noteuspto-grants-2003_02