HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl methylthiosulphonate → 5-Chloro-n-(methylthio)-n-2-propenyl-3-(trimethylsilyl)-2-thiophenecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl methylthiosulphonate | HCID 14573333 | — |
| Reactant | 5-Chloro-N-(2-propenyl)-3-(trimethylsilyl)-2-thiophenecarboxamide | HCID 18630152 | — |
| Reactant | N-Ethyl-N-(methylthio)-3-(trimethylsilyl)-2-thiophene-carboxamide | HCID 18630304 | — |
| Product | 5-Chloro-n-(methylthio)-n-2-propenyl-3-(trimethylsilyl)-2-thiophenecarboxamide | HCID 18630036 | — |
Reaction Steps
The compound of Example 262 (1.1 g) was reacted with 0.52 g of methyl methanethiosulfonate using procedure described for the preparation of the compound of Example 272. The title compound (0.6 g) was purified by flash chromatography with 2% ethyl acetate-hexane and recovered as a colorless oil. nD25 1.5698.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06521603B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-02d0406932384cb2a87478c8331913d2 |
| Source note | uspto-grants-2003_02 |