反应详情

温度

76 °C

A mixture of 2,4,5-trimethyloxazole (0.50 mL, 4.3 mmol), N-bromosuccinimide (0.77 g, 4.3 mmol) and benzoyl peroxide (0.21 g, 0.86 mmol) in carbon tetrachloride (4 mL) was heated at 76° C. under nitrogen atm.for 3 hrs. After cooling to rt, the solid was removed by filtration. The filtrate solution was washed with saturated aqueous NaHCO3 (20 mL) and concentrated. The residue was purified by flash column chromatography (SiO2; hexanes:ethyl acetate/4:1) to afford 2-(bromomethyl)-4,5-dimethyloxazole (64 mg) as an yellow oil.

1. temperatureAfter cooling to rt
2. customthe solid was removed by filtration
3. washThe filtrate solution was washed with saturated aqueous NaHCO3 (20 mL)
4. concentrationconcentrated
5. customThe residue was purified by flash column chromatography (SiO2; hexanes:ethyl acetate/4:1)