反应详情

温度

100 °C

To a stirred solution of 2-amino-4-methoxy-7-phenyl-benzothiazole (80 mg, 0.3 mmol) in dioxane (3 ml) was added pyridine-3-isothiocyanate (64 mg, 0.47 mmol) and the mixture heated to 100° C. for 69 h. After cooling to r.t. the resulting yellow suspension was filtered, washed with ether (5 ml) and dried under vacuum (0.05 mmHg, 50° C., to afford the title compound as a; light yellow solid (98 mg, 80% yield), MS: m/e=393.1 (M+H+).

1. temperatureAfter cooling to r.t. the resulting yellow suspension
2. filtrationwas filtered
3. washwashed with ether (5 ml)
4. customdried under vacuum (0.05 mmHg, 50° C.