Water → HCID 22283025, compound

HRID 1060293Notes

Reaction equation

HRID 1060293 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH:12]C(=O)O)[S:11][C:7]=2[C:6]([CH:16]=[CH2:17])=[CH:5][CH:4]=1.O>C(O)CO>[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([CH:16]=[CH2:17])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 962WaterHCID 22283075HCID 22283075, compound

Product 1

HCID 22283025HCID 22283025, compound

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Conditions

Temperature
100 °C

Procedure

(4-Methoxy-7-vinyl-benzothiazol-2-yl)-carbamic acid methyll ester was dissolved in ethylenglycol/2N KOH (2:1) and stirred at 100° C. for 3 hrs. Then water was added and the mixture was extracted with CH2Cl2, the organic phase was washed with brine and dried over MgSO4. After evaporation the residue was crystallized from CH2Cl2. White crystals (64%); F.p.: 155-159° C.

Workup

  1. extractionthe mixture was extracted with CH2Cl2
  2. washthe organic phase was washed with brine
  3. dry with materialdried over MgSO4
  4. customAfter evaporation the residue
  5. customwas crystallized from CH2Cl2
  6. custom155-159° C.

Sources & evidence

ORD record
ord-5d9d853d8ebb429aae92605a7c289c71
Source dataset
uspto-grants-2003_02
Patent number
US06521754B2

Reaction notes

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