Sodium Methoxide → (5-Methoxy-biphenyl-3-yl)-thiourea

HRID 1060333Notes

Reaction equation

HRID 1060333 reaction equation
C([NH:9][C:10]([NH:12][C:13]1[CH:14]=[C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1)=[S:11])(=O)C1C=CC=CC=1.C[O-].[Na+]>CO>[CH3:20][O:19][C:17]1[CH:18]=[C:13]([NH:12][C:10]([NH2:9])=[S:11])[CH:14]=[C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:16]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 222833191-Benzoyl-3-(5-methoxy-biphenyl-3-yl)-thiourea

Product 1

HCID 22283392(5-Methoxy-biphenyl-3-yl)-thioureaYield 88%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-Benzoyl-3-(5-methoxy-biphenyl-3-yl)-thiourea (183 mg, 0.51 mmol) in methanol (5 ml) are treated with sodium methoxide (5.4M in methanol, 0.14 ml) and the formed precipitate is filtered off. Washing with methanol yields the product (115 mg, 88%) as off-white powder. MS: m/e=258 (M+).

Workup

  1. filtrationthe formed precipitate is filtered off
  2. washWashing with methanol

Sources & evidence

ORD record
ord-6c43d1a9a5c642a0a740b98bffafbb15
Source dataset
uspto-grants-2003_02
Patent number
US06521754B2

Reaction notes

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