反应详情

温度

65 °C

1-Iodo-3,5-dinitrobenzene (1.8 g, 6.1 mmol) are dissolved in methanol (12 ml) and treated with a solution of sodium methoxide in methanol (5.4M, 1.2 ml). The mixture is then stirred at 65° C. for 52 h. After cooling to ambient temperature, water (50 ml) is added and the mixture extracted three times with ethyl acetate (50 ml). The combined organic layers are extracted with brine (100 ml), dried and evaporated to dryness. Flash chromatography (silica, eluent ethyl acetate/cyclohexane 1:1) affords the product (1.7 g, 99%) as light yellow solid. MS: m/e=279 (M+).

1. temperatureAfter cooling to ambient temperature
2. extractionthe mixture extracted three times with ethyl acetate (50 ml)
3. extractionThe combined organic layers are extracted with brine (100 ml)
4. customdried
5. customevaporated to dryness