反应详情

4-(4-Methoxy-3-nitro-phenyl)-morpholine (6 g) is hydrogenated in dichloromethane (100 ml) and methanol (600 ml) using palladium on carbon (10%, 600 mg) for 12 hours. The catalyst is removed by filtration and the solution evaporated in vacuo. Purification by flash chromatography (silica, eluent ethyl acetate/n-hexane 1:1, then) affords the product as off-white solid (4.6 g, 88%). MS: m/e=209 (M+H+).

1. customfor 12 hours
2. customThe catalyst is removed by filtration
3. customthe solution evaporated in vacuo
4. customPurification by flash chromatography (silica, eluent ethyl acetate/n-hexane 1:1