HRID1060437

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22571993

[4-(1,3-Dioxolan-2-yl)-2,6-dimethoxyphenyl]boronic acid

C11H15BO6

结构：COC(=O)[C@H](Cc1ccc(OS(=O)(=O)C(F)(F)F)cc1)NC(=O)c1c(Cl)cccc1Cl

HCID22970630

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](Cc1ccc(-c2c(OC)cc(C3OCCO3)cc2OC)cc1)NC(=O)c1c(Cl)cccc1Cl

HCID54069836

未命名化合物

PROCEDURE

实验过程

4-(1,3-Dioxolan-2-yl)-2,6-dimethoxybenzeneboronic acid was reacted with N-(2,6-dichlorobenzoyl)-O-(trifluoromethanesulfonyl)-L-tyrosine methyl ester in a similar manner as described in Example 7-2) to give N-(2,6-dichlorobenzoyl)-4-[4-(1,3-dioxolan-2-yl)-2,6-dimethoxyphenyl]-L-phenylalanine methyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ad33a321ebc344ebb418080f33c4eee1
来源数据集: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06521666B1
来源说明: uspto-grants-2003_02

反应 SMILES

[O:1]1[CH2:5][CH2:4][O:3][CH:2]1[C:6]1[CH:11]=[C:10]([O:12][CH3:13])[C:9](B(O)O)=[C:8]([O:17][CH3:18])[CH:7]=1.[CH3:19][O:20][C:21](=[O:49])[C@H:22]([CH2:34][C:35]1[CH:40]=[CH:39][C:38](OS(C(F)(F)F)(=O)=O)=[CH:37][CH:36]=1)[NH:23][C:24](=[O:33])[C:25]1[C:30]([Cl:31])=[CH:29][CH:28]=[CH:27][C:26]=1[Cl:32]>>[CH3:19][O:20][C:21](=[O:49])[C@H:22]([CH2:34][C:35]1[CH:36]=[CH:37][C:38]([C:9]2[C:10]([O:12][CH3:13])=[CH:11][C:6]([CH:2]3[O:3][CH2:4][CH2:5][O:1]3)=[CH:7][C:8]=2[O:17][CH3:18])=[CH:39][CH:40]=1)[NH:23][C:24](=[O:33])[C:25]1[C:26]([Cl:32])=[CH:27][CH:28]=[CH:29][C:30]=1[Cl:31]