HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 3,5-Dimethoxybenzyl tert-butyldiphenylsilyl ether
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 3,5-Dimethoxybenzyl alcohol | HCID 69718 | — |
| Reactant | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3,5-Dimethoxybenzyl tert-butyldiphenylsilyl ether | HCID 22571883 | 87.9% |
Reaction Steps
A mixture of 3,5-dimethoxybenzyl alcohol (4.0 g), tert-butyl-diphenylsilyl chloride (6.54 g) and imidazole (3.28 g) in DMF (60 mL) was stirred at room temperature for 24 h. DMF was evaporated and the residue was purified by column chromatography (silica gel; eluent: hexane to hexane/EtOAc 20%) to yield 8.5 g of 3,5-dimethoxybenzyl tert-butyldiphenylsilyl ether. ESMS: m/z 407 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06521666B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-fab6cf9405ac44258e70faa458d6f91c |
| Source note | uspto-grants-2003_02 |