HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroethyl Isothiocyanate → 2-Chloro-4-(2-thiazolinylamino)benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroethyl Isothiocyanate | HCID 138661 | — |
| Reactant | Methyl 4-Amino-2-chlorobenzoate | HCID 11839197 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Chloro-4-(2-thiazolinylamino)benzoic acid methyl ester | HCID 69564628 | — |
Reaction Steps
A mixture of 4-amino-2-chlorobenzoic acid methyl ester (0.5 g) and 2-chloroethylisothiocyanate (0.26 mL) in THF (20 mL) was refluxed for 24 h. THF was distilled and the residue was purified by column chromatography (silica gel: eluent: hexane/EtOAc 3:1-1:1) to yield 2-chloro-4-(2-thiazolinylamino)benzoic acid methyl ester (74 mg). ESMS: m/z 271 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06521666B1 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-d412ada58d2c44bcb6d2fd3509df2c39 |
| Source note | uspto-grants-2003_02 |