Hydrochloric Acid → HCID 69409074, compound

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Reaction Steps

A mixture of 1-benzyl-2-(4-nitrophenyl)-5-imidazole-acetic acid (2.19, 5.0 mmol), 10% palladium on carbon (0.10 g), 12 M HCl (3.0 ml), 96% ethanol (50 ml) and water (50 ml) was hydrogenated at 55 psi for 1.5 hours on a Parr shaker hydrogenation apparatus. The mixture was filtered through a celite pad and then through a fluted filter paper. Evaporation left the title compound, Compound 12, as 1.0 g orange solid. Rf=0.1 (silica, ethyl acetate/hexanes 1:1).

Provenance & Evidence