Formaldehyde → HCID 18628520, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 29.4 g (0.1 mol) of N-amino-N-2-hydroxyethyl-N′-(2,4-dichloro-5-methoxyphenyl)urea and 9 g (0.11 mol) of a 37% strength formaldehyde solution in 500 ml of methylene chloride was stirred at 42° C. for 2 h. After cooling, the reaction mixture was filtered with suction with about 300 ml of silica gel and washed with methylene chloride. Analysis by thin-layer chromatography gave a higher Rf value than that of the reaction mixture which had not been treated with silica gel and remained on the methyleneimino stage. Concentration under reduced pressure gave 27.8 g (81.8% of theory) of the title compound of m.p. 128-130° C.

Provenance & Evidence