Potassium Carbonate → HCID 9895687, compound

Participants

Reaction Steps

A solution of (2R,3R,4R,5S)-4-(benzoyloxy)-2-[6-[(2,2-diphenylethyl)amino]-2-({[2-(1-piperidinyl)-ethyl]amino}carbonyl)-9H-purin-9-yl]-5-[(ethylamino)carbonyl]tetrahydro-3-furanyl benzoate (Preparation 7) (104 mg, 0.12 mmol) in methanol (3 ml) was treated with potassium carbonate (100 mg, 0.72 mmol). The mixture was stirred at room temperature for 30 minutes. The solvent was removed under reduced pressure and the residue was partitioned between ethyl acetate and water. The organic layer was separated, dried with anhydrous magnesium sulphate, filtered and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel eluting with dichloromethane: methanol (90:10 by volume) to afford the title compound as a white solid (44 mg).

Provenance & Evidence