反应详情

A solution of methyl 9-{(2R,3R,4R,5S)-3,4-bis(benzoyloxy)-5-[(ethylamino)carbonyl]-tetrahydro-2-furanyl}-6-[(2,2-diphenylethyl)amino]-9H-purine-2-carboxylate (Preparation 10) (3.4 g, 4.5 mmol) and sodium carbonate (50 mg) in dry methanol (60 ml) was stirred at room temperature for four hours. The solvent was removed under reduced pressure and the residue was taken up in a mixture of dichloromethane:methanol (95:5 by volume, 60 ml). Inorganic salts were filtered off and the filtrate was evaporated under reduced pressure. The residue was triturated with ether, filtered off and dried to yield the target compound as a white solid (2.4 g).

1. customThe solvent was removed under reduced pressure
2. additionthe residue was taken up in a mixture of dichloromethane:methanol (95:5 by volume, 60 ml)
3. filtrationInorganic salts were filtered off
4. customthe filtrate was evaporated under reduced pressure
5. customThe residue was triturated with ether
6. filtrationfiltered off
7. customdried