HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 5-Bromo-7-chloroindoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 1-(5-Bromo-7-chloro-2,3-dihydro-1H-indol-1-yl)ethan-1-one | HCID 18629269 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Bromo-7-chloroindoline | HCID 16789164 | 87.8% |
Reaction Steps
Part B: 1-acetyl-5-bromo-7-chloroindoline (1.17 g) was dissolved in a mixture of ethanol (15 mL) and water (8 mL) containing KOH (0.5 g) and heated to reflux for 2 h. The reaction was partitioned between EtOAc (100 mL) and water (20 mL). The organic extract was washed with brine (20 mL), dried and stripped in vacuo to give 5-bromo-7-chloroindoline (0.87 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06525056B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-8ee73df8cb29452c817807b2032d3d5d |
| Source note | uspto-grants-2003_02 |