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Pseudosaccharin chloride → HCID 178446098、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pseudosaccharin chloride | HCID 64783 | — |
| 反応物 | 2-amino-N-[3-cyano-1-(1-ethyl-propyl)-pyrrolidin-3-yl]-3-cyclohexyl-propionamide bis hydrochloride salt | HCID 86585202 | — |
| 生成物 | HCID 178446098 | HCID 178446098 | — |
反応手順
The title compound was prepared starting from 3-chloro benzo[d]isothiazole 1,1-dioxide and 2-amino-N-[3-cyano-1-(1-ethyl-propyl)-pyrrolidin-3-yl]-3-cyclohexyl-propionamide bis hydrochloride salt according to the procedure from Examplel 0, except that the compound was further purified by HPLC using a 20×250 mm C18 reverse phase column with the method being 40% acetonitrile in water to acetonitrile. MS, m/z 500=M+1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06525052B2 |
| 出典データセット | uspto-grants-2003_02 |
| ORD ID | ord-02aace188bb24c11a1b27f72762e2251 |
| 出典メモ | uspto-grants-2003_02 |