Dimethylsulphamoyl chloride → [4-(4-amino-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)butyl]-N,N-dimethylsulfamide

HRID 1060688Notes

Reaction equation

[CH3:1][N:2]([CH3:7])[S:3](Cl)(=[O:5])=[O:4].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:21]2[C:20]([CH3:22])=[C:19]([CH3:23])[N:18]=[C:17]([NH2:24])[C:16]=2[N:15]=[CH:14]1>>[NH2:24][C:17]1[C:16]2[N:15]=[CH:14][N:13]([CH2:12][CH2:11][CH2:10][CH2:9][NH:8][S:3]([N:2]([CH3:7])[CH3:1])(=[O:5])=[O:4])[C:21]=2[C:20]([CH3:22])=[C:19]([CH3:23])[N:18]=1

Participants

Reactant 2

HCID 83372Dimethylsulphamoyl chloride

HCID 219738081-(4-aminobutyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine

Product 1

HCID 22499150[4-(4-amino-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)butyl]-N,N-dimethylsulfamide

Procedure

Using the method of Examples 15-29, dimethylsulfamoyl chloride was reacted with 1-(4-aminobutyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired product. The observed accurate mass was 341.1770.

Sources & evidence

ORD record: ord-dfe599eab7b24ab0a4fbb6579e4b19a2
Source dataset: uspto-grants-2003_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06525064B1

Reaction notes

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