反应详情

A mixture of 2-biphenyl-3-yl-4-methylpent-4-enoic acid (250 mg, 0.9 mmol), prepared as in Example 2, and 5% Pd/C (50 mg) in 10 ml of ethanol was hydrogenated (40 psi) for 2 hours. The mixture was filtered and the filtrate concentrated to provide 2-biphenyl-3-yl-4-methylpentanoic acid (250 mg, 0.9 mmol). 1H NMR (DMSO-d6): 1.01 (d, 6H), 1.81-1.85 (m, 3H), 3.68 (dd, 1H), 7.08 (d, 1H), 7.24-7.37 (m, 8H). LCMS: 269.1 (M+H+).

1. customfor 2 hours
2. filtrationThe mixture was filtered
3. concentrationthe filtrate concentrated