Sodium Hydroxide → HCID 69940979, compound

HRID 1060777Notes

Reaction equation

HRID 1060777 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7](=[C:16]3[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[NH:18][C:17]3=[O:25])[CH2:8][CH:9]2[CH2:12][C:13]([OH:15])=[O:14])=[CH:5][CH:4]=1.[OH-].[Na+:27]>O>[Na+:27].[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([C:7](=[C:16]3[C:24]4[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=4)[NH:18][C:17]3=[O:25])[CH2:8][CH:9]2[CH2:12][C:13]([O-:15])=[O:14])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57151150HCID 57151150, compound

Product 1

HCID 69940979HCID 69940979, compoundYield 99.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A suspension of 8 g [6-methoxy-3-(2-oxo-1,2-dihydroindol-3-ylidene)indan-1-yl]-acetic acid in 60 ml of water was added to 0.9 g of sodium hydroxide in 10 ml of water. The mixture was stirred at room temperature for 30 minutes and filtered. The filtrate was frozen and lyophilized to give 8 g of [6-methoxy-3-(2-oxo-1,2-dihydroindol-3-ylidene)-indan-1-yl]-acetic acid sodium salt.

Workup

  1. filtrationfiltered
  2. temperatureThe filtrate was frozen

Sources & evidence

ORD record
ord-eb3d3d1f552745faa87dcdc0aa196300
Source dataset
uspto-grants-2003_02
Patent number
US06525072B1

Reaction notes

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