Potassium Carbonate → HCID 18629512, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3,5-dichloro-4-fluorobenzotrifluoride (4.79 g) in dimethylformamide (25 ml) was added 3-ethynylindole (2.9 g) and potassium carbonate (2.84 g), the mixture was heated at 90° C. for 3 hours under an atmosphere of nitrogen and then left to stir overnight at room temperature. The reaction was diluted with water (100 ml) and extracted with hexane (2×100 ml). The organic fractions were separated, combined, evaporated to dryness and purified by column chromatography on silica gel (300 g) eluted with hexane: ethylacetate (97:3) to give the title compound as a white solid (1.3 g), m.p. 120-122° C. δ(CDCl3): 6.9-7.8 (7H,m), 3.3 (3H,s).

Provenance & Evidence