HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3,4-Bis(methylsulfonyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3,4-Bis-methanesulfonyl-benzoic acid tert-butyl ester | HCID 69431571 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3,4-Bis(methylsulfonyl)benzoic acid | HCID 22397432 | 95.2% |
Reaction Steps
To 3,4-bis-methanesulfonyl-benzoic acid tert-butyl ester (0.366 g) in dichloromethane was added trifluoroacetic acid and the reaction mixture was stirred for 3 hours. The mixture was evaporated and trituration of the residue with diethyl ether gave the title compound (0.29 g; MS: APCI+(M+H) 279).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06525070B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-438397359b0349789d0c29fcb3dddf15 |
| Source note | uspto-grants-2003_02 |