2-Dimethylaminopyridine → HCID 10275329, compound

Participants

Reaction Steps

A mixture of 1-[2-(4-chloro-2,6-dimethyl-phenoxy)-3,6-dimethyl-pyridin-4-yl]-2,2,2-trifluoro-ethanol (21 mg, 0.0589 mmol), propyl isocyanate (0.1 ml), dimethylaminopyridine (20 mg) in dichloromethane (2 ml) was heated at reflux for 6 hrs. The mixture was quenched with water and extracted with chloroform. The organic layer was separated, dried and concentrated to give 23 mg of yellow solid. The solid was purified by preparative thin layer chromatography (run in 20% ethyl acetate in hexane) to give the title compound as a white solid.

Provenance & Evidence