Methyl Isocyanate → HCID 70026654, compound

Participants

Reaction Steps

A mixture of 1-[2,5,6-trimethyl-7-(2,4,6-trimethyl-phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-propan-1-ol(62 mg, 0.184 mmol), methyl isocyanate (0.25 ml), dimethylaminopyridine (20 mg) in dichloromethane (2 ml) was heated at reflux for 1 hr. Additional methyl isocyanate (0.25 ml) was added and the resulting mixture was stirred at room temperature overnight. The mixture was quenched with water and extracted with chloroform. The organic layer was separated, dried and concentrated to give a yellow foam (95 mg). The foam was purified by preparative thin layer chromatography plate in 10% methanol in chloroform, then in 20% methanol in chloroform as solvent to give the title compound (29 mg) as an off-white solid.

Provenance & Evidence