3-Hydroxybenzoic Acid → HCID 86758852, compound

Participants

Reaction Steps

A solution of 3-hydroxybenzoic acid (0.07 g, 0.51 mmol), methanesulfonyl chloride(0.15 g, 1.29 mmol), and triethylamine (0.16g, 1.54 mmol) in CH2Cl2 (3 mL) was stirred for 1 hr at 0° C. The reaction was allowed to come to room temperature and 3-amino-N-[1-(4-cyano-3-fluoro-phenyl)-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-propionamide dihydrochloride and triethylamine (0.10 g, 1.03 mmol) were added. After stirring overnight, H2O (1 mL) was added and the mixture was extracted with CH2Cl2 (3×5 mL). The combined organic layers were dried (Na2SO4), filtered, and concentrated in vacuo to provide the title compound.

Provenance & Evidence