HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-(1-hydroxy-1-pyridin-3-yl-methyl)-benzonitrile → 2-Fluoro-4-(1-pyridin-3-yl-methanoyl)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-(1-hydroxy-1-pyridin-3-yl-methyl)-benzonitrile | HCID 18629452 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Fluoro-4-(1-pyridin-3-yl-methanoyl)-benzonitrile | HCID 18629448 | — |
Reaction Steps
2-Fluoro-4-(1-hydroxy-1-pyridin-3-yl-methyl)-benzonitrile (1.04 g, 4.55 mmol) and MnO2 (3.96 g, 45.5 mmol) were stirred in CH2Cl2 (100 mL) for 4 h. The solution was filtered through a celite pad and concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06525074B2 |
| Source dataset | uspto-grants-2003_02 |
| ORD ID | ord-cd9fa62e3ee24648aad97c11615e0db5 |
| Source note | uspto-grants-2003_02 |